New Study Uncovers Gut Health's Role in Post-COVID Fatigue

A research group at the Medical University of Vienna has uncovered fresh details about post-COVID syndrome (PCS) and the significance of maintaining a healthy gut. This investigation, detailed in the journal Allergy, reveals that individuals with PCS exhibit modified inflammatory indicators along with an impaired intestinal lining, potentially leading to ongoing viral exhaustion symptoms.

Led by Eva Untersmayr-Elsenhuber from MedUni Vienna’s Center for Pathophysiology, Infectiology and Immunology, the research team scrutinized information gathered through a prospective observational study. They investigated how SARS-CoV-2 infections progressed alongside gastrointestinal symptoms both prior to, throughout, and following the illness. Moreover, they conducted an analysis of blood, saliva, and fecal specimens taken from individuals with post-COVID syndrome (PCS).

The findings indicate that individuals who suffer from prior gastrointestinal issues face a higher likelihood of experiencing PCS-related fatigue. Additionally, notable alterations were observed in specific biological markers. Specifically, those with PCS exhibited elevated ratios of LBP/sCD14 along with decreased levels of IL-33, suggesting modifications in immune response and diminished integrity of the gut lining. Furthermore, heightened concentrations of IL-6 were detected, recognized as indicators of widespread inflammation within the body.

Our findings indicate that infection with SARS-CoV-2 may lead to prolonged impacts on the immune system and gut health, which play a role in the onset of post-COVID syndrome.

Eva Untersmayr-Elsenhuber from the Centre for Pathophysiology, Infectious Disease, and Immunology at MedUni Vienna

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