Kelly Osbourne's 'Ozempic Face' Transformation in Side-by-Side Photos

Kelly Osbourne's full journey of losing weighthas made her almost unidentifiable. The "Fashion Police" veteran's striking transformation is highlighted even more in before-and-after images from 2019 and 2026. In the 2026 picture, Osbourne's face looks more hollow because of her sharp cheekbones, noticeable jawline, and the general reduction in facial fullness. On the other hand, her lips appear fuller than previously. Her facial characteristics also show considerable signs of aging over the course of seven years.

Many have described Osbourne as suffering from a case ofLifestyle changes, which are one of the many side effects of diabetes medicationsthat Hollywood employs for shedding pounds. Talking aboutCleveland Clinic,Endocrinologist Vinni Makin, MD, stated, "The term 'Ozempic face' describes the facial changes that can occur with quick weight loss." She added, "It is marked by a gaunt appearance, hollowed cheeks, additional wrinkles, and sagging skin on the face and neck." Much of these features align with the changes seen in Osborne's before-and-after photographs.

However, in April 2024ExtraIn an interview, the reality TV personality stated that Ozempic was not responsible for the 85-pound weight loss she experienced after giving birth to her son in 2022. She credited her results to cutting out sugar and carbohydrates from her diet. Furthermore, in February 2024E! NewsIn an interview, Osbourne expressed her support for individuals who decided to use Ozempic for weight loss. She even suggested that some of the drug's strongest critics were actually upset because they couldn't afford it.

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The cause of Kelly Osbourne's weight loss could be more intricate than what is commonly assumed.

Kelly Osbourne didn't hold back when responding to those who labeled her as one of thecelebrities who appeared completely different after taking weight loss medications such as Ozempic.To the individuals who continue to believe they are being humorous and cruel by leaving comments such as 'Are you sick,' or 'Stop using Ozempic, you don't look right,' Osbourne started in a now-removed Instagram video posted in December 2025 (viaUSA Today). "My father just passed away, and I'm doing my best, and the only thing keeping me going right now is my family." The reality TV star also directly told her critics to "go to hell."

Given that Osbourne has faced remarks about her physique for years, it's not surprising that her reaction to the online comments was so direct. In a 2024 episode of"The Osbournes Podcast,"She remembered how a agency executive had privately informed her 18-year-old self that she was "too heavy for TV" and could have a chance on the big screen if she lost some weight. Osbourne described the hurtful and entirely unacceptable remark as "the most insulting f***ing thing."

In the meantime, when she participated in a panel in May 2025, Osbourne shared how nearly every article that referenced her over the years included some remark about her weight. Certain individuals had even taken it upon themselves to inform her that she would look completely transformed if she ever lost weight (viaPeople) However, after losing a substantial amount of weight, Osbourne has still encountered criticism.

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